Biological Screening and Development Core Facility

The Biological Screening and Development (BSD) Core provides access to equipment and expertise for the biological and translational assessment of chemical compounds. The core offers many services to the Notre Dame Research community; including consulting, design, development, miniaturization, and implementation of high-throughput assays to your research needs. Additionally, the core can provide expertise and technologies to assist with and perform in vivoPK, PD and bio-distribution studies for lead compound development. The core is capable of generating and purifying recombinant proteins for numerous in vitroassays. And we offer a full range of ADME-T services for small molecule development using high-throughput pre-clinical screenings; these assays include: Microsomal Stability, Primary Hepatocyte Toxicity, Caco-2 Permeability and Transport, Plasma Stability, Plasma protein binding, hERG Interaction, AMES Mutagenicity Test, Blood-Brain Barrier Permeability, CYP Inhibition, and CYP Induction.

For use of screening or assay development services or to request a quote for inclusion in a grant submission, please contact bsdc@nd.edu.